Intrinsic Role of Polysialylated Neural Cell Adhesion Molecule in Photic Phase Resetting of the Mammalian Circadian Clock
نویسندگان
چکیده
منابع مشابه
Intrinsic role of polysialylated neural cell adhesion molecule in photic phase resetting of the Mammalian circadian clock.
The suprachiasmatic nuclei (SCN), the location of the mammalian circadian clock, are one of the few adult brain regions that express the highly polysialylated form of neural cell adhesion molecule (PSA-NCAM). A role for the polysialic acid (PSA) component of PSA-NCAM, which is known to promote tissue plasticity, has been reported for photic entrainment of circadian rhythmicity in vivo. The in v...
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The suprachiasmatic nuclei (SCN) express the highly polysialylated form of the neural cell adhesion molecule (NCAM) that has been proposed to promote plasticity in the adult brain. To investigate a role for NCAM in SCN circadian clock function, we examined the daily locomotor rhythm of mice homozygous for a mutation, Ncamtm1Cwr, which results in deletion of the NCAM-180 isoform that in brain ca...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2003
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.23-02-00652.2003